It is well known that antibiotics inhibit growth of certain pathogenic microorganisms and can be used to boost piglet performance. However, the demand for antibiotic-free pork and the reduction of antibiotics as growth promoters in pig production creates a need for holistic approaches to sustain intestinal health and thriving piglets. Protease supplementation helps piglets to digest protein, which minimizes many factors which are detrimental to gut health. Similarly, certain organic acids can reduce growth of pathogenic bacteria in the gut, which improves gut health and performance.