Taking bioavailability measurement to the next level
Mineral deposition and immune markers are not direct indicators of the value of different mineral sources to the animal. Mineral deposition measures the amount of minerals stored by the animal – not the amount taken in or used. Novus is improving our understanding of tissue responses to trace mineral sources using molecular biology techniques.
Metallothionein (MT) Expression
MT expression is widely recognized in human medical research as a marker of cellular Zn uptake. As Zn absorption increases, MT mRNA and protein increase. Novus has developed a patent-pending, real-time polymerase chain reaction (RTPCR) assay to measure the expression of metallothionein as a marker for both zinc status and bioavailability. The graph shows that MINTREX® Zn-fed animals expressed significantly greater MT mRNA than all other treatments. These results indicate that MINTREX® Zn was more bioavailable than any other Zn source. Higher trace mineral stability and bioavailability means better animal performance, improved overall health and reduced environmental impact by lowering the total amount of supplemental minerals fed.
Higher bioavailability drives ‘Reduce and Replace’ strategy
A recent trial with a major US poultry producer (April 2009) evaluated performance, yield and welfare parameters in birds fed diets containing either Zn, Cu and Mn (100:125:90 mg/kg) as sulphates or MINTREX Zn, Cu and Mn (32:8:32 mg/kg). All other components of the diet were identical between the two groups. 100: 125: 90 (in Table 1.).
Studies showed no difference in performance but a significant improvement in foot pad health when MINTREX® was the mineral source. There was also a significant redction in trace mineral content of poultry manure with the OTM source. These results demonstrate how the MINTREX® ‘Reduce and Replace’ strategy delivers performance and improved animal welfare while reducing the environmental impact of poultry production units.
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**Reference available on request