In a recent research study entitled “Identification of potential biomarkers for gut barrier failure in broiler chickens,” published in Frontiers in Veterinary Sciences, Novus International, Inc., and University of Arkansas, researchers used coccidiosis over-vaccination to trigger a gut health challenge in broiler chickens fed a wheat–barley–rye diet. The overall growth performance and feed efficiency were severely reduced by this gut barrier failure (GBF) model. The results of this study are in agreement with previous studies that concluded high NSP diets compromised growth performance in chickens.
The purpose of the study was not to determine the individual effects of diet ingredients or coccidia challenge, but rather to determine potential biomarkers that may be used to define GBF in future studies. Biomarkers could be useful to monitor poultry health and understand disease mechanisms.